Author: Professor JB Jadin
Provincial Institut voor Hygiene, Antwerpen, Belgium
This article was presented at the International Meeting
'RICKETTSIOLOGY: The present and the future'
Palermo ( Italy) 21-28 June 1987
Most nervous diseases have been described by symptoms proceeding from observations made by clinicians rather than by histo-pathological and biological studies.
In this paper we want to show how, after fifty years of research on the subject with Henri Baruk, we think we have come to a turning point on neurology, neurological etiology.
Consequently, a number of nervous diseases considered, up to now, as incurable, can be successfully treated for as much as their physical state is not too impaired.
Most nervous diseases have been described by symptoms observed clinically, rather than biological studies and histopathology.
Undoubtedly, most diseases are well known and their etiomology has been identified. Nevertheless quite a number of them, for instance the disease of Guilain Barre, syringo-myelie, disease of Creutzfeldt-Jacob, are described as viral affections, due to one of many viruses which attack man during life and are, one after another, being isolated.
Observations which we have kept on since more than fifty years, have led us to think that protozoa viruses and bacteria, if associated, may be very important in nervous diseases.
(Jadin J.B., Giroud P., Jadin J.M., 1984)
The damage caused on the brain by trypanosoma in Central Africa is well known. But often trypanosoma is not only responsible for the bad physical conditions observed during this terrible disease. Indeed, in many regions, trypanosoma live in symbiosis with man without any effect. For instance, in Zimbabwe where Blair (1939) observed the presence of subjects infected by Trypasonoma rhodesiense, without any ill effect. In 1963, with Limbos, we isolated a feebly virulent Trypasonoma gambiense in a healthy subject coming from Zaire. ne should not forget the exceptional case stated by Lapeyssonie, of a woman who, 21 years after a laboratory tested infection, was still in perfect health. In a recent case originally from Matadi, (Zaire) we have found a very high level of Rickettsial antibodies at the same time as Trypasonoma.
This induced us to examine a series of sera coming from subjects infected, some by T. rhodesiense , others by T. gambiense. These cases had been parasitologically tested.
Ten sera of T. rhodesiense came from Zambia while ten sera of T. gambiense came from patients in the Ivory Coast. These twenty sera all had active anti-rickettsial antibodies, especially for Rickettsia mooseri. Moreover, four Rhodesiense sera reacted to Coxiella burneti while two sera of the T. gambiense group reacted to Chlamydiae.
We have tried to find out what is the reaction of patients suffering from Chagas sickness. Everyone knows the importance of this parasite in South America. On eight sera of the patients infected by Trypasonoma Cruzi, six had anti Rickettsia mooseri, while three had active antibodies to C. burnetti. These facts should make clear the great importance of parasital and bacterial association, where often nervous symptoms are also to be found.
Bearing in the mind the most worldly wide distributed disease, paludism, we are convinced that Plasmodium is not the only reason of high death rate so often caused by cerebral parasitism.
In 1949, together with Paul Giroud, we followed up several cases near Astrida (Butare, Rwanda). Plasmodium Falciparum was found abundantly in all cases, but inoculation of dying people, has allowed us to isolate several strains of Rickettsia Burnetti. In the years following, together with Paul Giroud, we established the role of Chlamydia or neo-rickettsia, during several epidemics occurring in Kivu, of meningo-encaphilitis, encapho-myocarditis where protozoa were observed together with neo-rickettsia (Jadin and Giroud, 1957).
We also want to mention that toxoplasma living inside cerebral cysts, may act differently following a Rickettsial infection. We have thus observed several patients having epileptical fits, rapidly getting cured by antibiotical treatment.
Since forty years that we systematically look for anti rickettsial antibodies in Europe and Africa, we have made evident, the great importance of those etiologic agents in nervous diseases.
We have made actually more than 200 000 examinations, which confirm our convictions. Rickettsia and their transmitters are to be found the world over. Though they are less frequent in Western Europe, they are quite as important and yet totally ignored by many epidiomologists.
During epidemics in Russia, as well as in Poland, research has been made which made it possible to isolate the infecting agents from sick people as well as from those presenting no symptoms whatever. Still, the emigrated people, though not sick themselves but having lived among sick people are responsible for introducing the typhus in the USA. This form of disappearing and reappearing disease is commonly known as Brills Disease.
As early as 1911, Charles Nicolle noted the extreme importance of unapparent diseases, firstly noted in guinea pigs, and later on, in man (Nicolle, 1925).
Rickettsia are, without doubt, the cause of many nervous troubles. Multiple Sclerosis is among those we have done most research on. Following Paul Giroud and Paul Le Gac, we have shown the presence of anti-rickettsial antibodies in quite a number of patients suffering from M.S. In some cases, we could find which Rickettsia was the cause. (Jadin, 1962).
P. Le Gac and associates' treatment with large spectrum antibiotics, proves to be a decisive argument. Hundreds of patients can walk, see and live once more a normal life ( Legag,1986) .
These last months, together with fellow workers, we have shown that many other diseases such as epilepsy, Parkinsons Disease, caracterial children are nearly always due to Rickettsia. (Le Gac 1986; Bottero, 1986).
Keeping in mind a, Henri Baruk comes to the conclusion that they lead to a turning point in neurology and thus to its treatment of a patient if is not in too poor a condition.
We use the pulse antibiotherapy (bacteriostatic + bactericidal), probiotics, antifungal, PPI and vitamins B complex on various conditions since 1992 in South Africa and worldwide.
The reason we carry on the same way is our success rate.
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